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Updated: Jan 25, 2026

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
Published on: September 16, 2020
Current perspectives on established and novel therapies for pathological neovascularization in retinal disease
Matthew Campbell1, Sarah L Doyle2
1Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.
Abstract:
Neovascularization is a hallmark pathology of numerous retinal diseases from diabetic retinopathy (DR) to age-related related macular degeneration (AMD). Over the past 2 decades, the rise of anti-VEGF based medications for neovascular eye conditions has revolutionized the treatment paradigm for patients and preserved the vision of millions. With any form of therapy however, there remain pitfalls and areas for improved interventions. Here, we succinctly present some current views on treatment options for patients with retinal and choroidal neovascularization. We also highlight some of the most promising therapeutic strategies currently being developed and where these therapies may fit with the current clinical standard of care.
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