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The relationship between deep medullary veins score and the severity and distribution of intracranial microbleeds

Ruiting Zhang1, Qingqing Li1, Ying Zhou1

  • 1Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, 88# Jiefang Road, Hangzhou, China.

Neuroimage. Clinical
|May 1, 2019
PubMed
Abstract

Insights

Deep medullary vein (DMV) disruption is linked to extensive microbleeds in patients with cerebral small vessel disease (cSVD). This finding highlights the role of venous changes in the development of non-strict lobar cerebral microbleeds.

Area of Science:

  • Neurology
  • Radiology
  • Vascular Biology

Background:

  • Cerebral microbleeds are common in the elderly, increasing risks for stroke and cognitive decline.
  • Previous research on microbleeds primarily focused on arterial and capillary pathology.
  • The link between venous disruption and microbleeds remains under-investigated.

Purpose of the Study:

  • To assess deep medullary vein (DMV) disruption in vivo.
  • To correlate DMV disruption with the severity and distribution of intracranial microbleeds in cerebral small vessel disease (cSVD) patients.

Main Methods:

  • Retrospective analysis of 369 cSVD patients' clinical, laboratory, and MRI data.
  • Utilized susceptibility-weighted imaging (SWI) for DMV assessment and microbleed evaluation.
  • Calculated a brain region-based DMVs visual score and analyzed microbleed number and distribution.

Main Results:

  • Higher DMVs scores were independently associated with extensive microbleeds (OR=1.108, p=0.03).
  • DMVs disruption was also linked to non-strict lobar microbleeds (OR=1.106, p=0.016).
  • No significant association was found between DMVs score and strict lobar microbleeds (p=0.307).

Conclusions:

  • Deep medullary vein (DMV) disruption may contribute to the development of extensive microbleeds.
  • This association is particularly evident for non-strict lobar cerebral microbleeds.
  • Venous disruption is a potential factor in cSVD pathogenesis.
Keywords:
Cerebral microbleedsCerebral small vessel diseaseDeep medullary veinsSusceptibility-weighted images

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