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Updated: Jan 25, 2026
03:37
Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
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Safety of 6000 intravitreal dexamethasone implants
Bindu Rajesh1, Javier Zarranz-Ventura2, Adrian T Fung3,4
1Khoo Teck Puat Hospital, Singapore, Singapore.
The British Journal of Ophthalmology
|May 2, 2019
Summary
Intravitreal dexamethasone implants are generally safe for retinal conditions, with cataract progression and elevated intraocular pressure being the most common manageable side effects in this large real-world study.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Pharmacology
Background:
- Intravitreal corticosteroid injections are used for various retinal conditions.
- The safety profile of dexamethasone implants in real-world settings requires comprehensive evaluation.
Purpose of the Study:
- To assess the real-life safety of intravitreal dexamethasone implant injections (700 µg) across diverse retinal pathologies.
- To identify and quantify adverse events associated with this treatment modality.
Main Methods:
- Retrospective multicenter analysis of 6015 intravitreal dexamethasone implant injections in 2736 eyes.
- Evaluation of adverse events including glaucoma, cataract, retinal detachment, and endophthalmitis over an average follow-up of 18 months.
Main Results:
- Cataract requiring surgery occurred in 32.5% of phakic eyes; 14.6% had visually insignificant progression.
- Intraocular pressure (IOP) rise (>25 mm Hg) occurred in 26.5% of eyes, managed medically in over 90%.
- Serious adverse events like endophthalmitis (0.07%) and retinal detachment (0.03%) were rare.
Conclusions:
- Intravitreal dexamethasone implants demonstrate a manageable safety profile for various retinal conditions in real-world practice.
- Cataract progression and IOP elevation are the most frequent side effects, typically responsive to medical or surgical management.
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