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Does an abnormally elevated maternal alkaline phosphatase pose problems for the fetus?

Sarah McErlean1, Chris King1

  • 1Obstetrics and Gynaecology, Letterkenny University Hospital, Letterkenny, Ireland.

BMJ Case Reports
|May 2, 2019
PubMed

We report a potential association between an abnormally raised pregnancy level of alkaline phosphatase (ALP) and intrauterine growth restriction (IUGR). There are few reports of women with abnormally high ALP during pregnancy. However, there is work to suggest an association with placental insufficiency, low birth weight and preterm delivery. In conjunction with a rising ALP, fetal IUGR and intermittent absence of umbilical artery end diastolic flow had evolved. A greatly elevated ALP may be a marker for placental insufficiency and IUGR.

Keywords:
materno-fetal medicinepregnancy

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