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Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage

Jun-Jie Yuan1, Qin Zhang1, Chang-Xiong Gong1

  • 1Department of Neurology, Xinqiao Hospital, The Army Medical University, Third Military Medical University, Chongqing 400037, China.

Bioscience Reports
|May 2, 2019
PubMed

Insights

Young plasma therapy shows promise for acute brain injury in aging rodents. It reduced mortality and neurological deficits, potentially by increasing insulin-like growth factor 1 (IGF-1) levels, offering a novel therapeutic avenue.

Area of Science:

  • Neuroscience
  • Gerontology
  • Regenerative Medicine

Background:

  • Aging impairs brain function and worsens acute brain damage.
  • Young plasma has shown potential to reverse age-related decline in biofunctions.
  • Intracerebral hemorrhage (ICH) is a severe form of acute brain injury often exacerbated by aging.

Purpose of the Study:

  • To investigate the neuroprotective effects of young plasma in aging rodents with ICH.
  • To identify circulating factors in young plasma that may mediate these protective effects.
  • To explore the role of insulin-like growth factor 1 (IGF-1) in aging-related brain injury and its response to young plasma.

Main Methods:

  • Administration of young plasma to aging ICH rodent models.
  • Assessment of mortality, neurological deficit scores, brain water content, and neuronal survival.
  • Proteomics analysis to identify differential circulating factors between age groups.
  • Enzyme-linked immunosorbent assay (ELISA) to quantify IGF-1 levels in plasma and brain tissue.
  • Administration of IGF-1 to aging ICH rodents to evaluate its therapeutic effect.

Main Results:

  • Young plasma significantly reduced mortality and neurological deficits in aging ICH rodents.
  • Proteomics revealed age-dependent changes in plasma factors, with IGF-1 notably decreased in older individuals.
  • Young plasma treatment restored decreased brain IGF-1 levels in aging ICH rats.
  • Direct administration of IGF-1 ameliorated acute brain injury in aging ICH rodents.

Conclusions:

  • Young plasma possesses neuroprotective properties against acute brain injury in aging.
  • Circulating factors, particularly IGF-1, transferred via young plasma may exert therapeutic effects.
  • Young plasma represents a potential novel therapeutic strategy for age-related acute brain injury.

Keywords:
AgingIGF-1acute brain injuryintracerebral hemorrhageyoung plasma

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