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Angiogenic factor from human term placenta. Purification and partial characterization.

H Burgos

    European Journal of Clinical Investigation
    |December 1, 1986
    PubMed
    Summary
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    Researchers identified a low molecular weight angiogenic and mitogenic factor from human amniochorion. This discovery may enhance wound healing treatments for chronic ulcers, burns, and general wounds.

    Area of Science:

    • Biochemistry
    • Regenerative Medicine
    • Biotechnology

    Background:

    • Human amniochorion and placenta contain angiogenic and growth-promoting factors.
    • These factors are typically released as high molecular weight components associated with carrier proteins.
    • The therapeutic potential of these factors for wound healing is significant.

    Purpose of the Study:

    • To isolate and characterize angiogenic and mitogenic factors from human amniochorion and placenta.
    • To investigate the potential application of these factors in wound healing.
    • To explore the therapeutic use of purified angiogenic factors.

    Main Methods:

    • Extraction of factors using 10% propan-2-ol, distilled water, and Tris/HCl buffer with NaCl.
    • Isolation via adsorption chromatography on DEAE-Sepharose CL6B.

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  • Fractionation using size-exclusion chromatography on Sephacryl S-300.

    • Main Results:

    • A low molecular weight component (400-1100 Da) with angiogenic and mitogenic activity was isolated.
    • Physicochemical properties suggest the active component is a peptide.
    • The presence of this factor in amniochorion explains its efficacy in healing chronic ulcers.

    Conclusions:

    • Human amniochorion contains a potent low molecular weight angiogenic and mitogenic peptide.
    • This factor holds promise for accelerating the healing of chronic ulcers, burns, and other wounds.
    • Purified angiogenic factor can be developed for broader therapeutic applications in tissue regeneration.