Related Experiment Video

Updated: Jan 25, 2026

Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension
09:23

Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension

Published on: February 11, 2017

17.4K

How Hypertension Affects Heart Metabolism

Agnieszka Polak-Iwaniuk1, Ewa Harasim-Symbor2, Karolina Gołaszewska2

  • 1Faculty of Health Sciences, Lomza State University of Applied Sciences, Łomża, Poland.

Frontiers in Physiology
|May 2, 2019
PubMed

Insights

Hypertension, a common cardiovascular disease, disrupts heart metabolism by increasing glucose utilization before structural changes occur. This study explores these metabolic shifts in cardiac muscle in human and animal models.

Area of Science:

  • Cardiovascular Physiology
  • Metabolic Research
  • Cardiac Metabolism

Background:

  • Hypertension is a leading cardiovascular disease, often preceding heart failure.
  • Hypertensive individuals exhibit systemic metabolic issues like hyperlipidemia, hyperglycemia, and insulin resistance.
  • Cardiac metabolism is sensitive to hormonal changes and substrate availability, making it vulnerable to systemic metabolic disturbances.

Purpose of the Study:

  • To investigate the impact of hypertension on cardiac metabolism.
  • To examine the shift in substrate utilization in the heart during hypertension.
  • To review findings across human and animal models of hypertension.

Main Methods:

  • Review of existing literature on hypertension and cardiac metabolism.
  • Analysis of studies focusing on substrate preference in hypertensive hearts.
  • Inclusion of data from both human patients and common animal models of hypertension.

Main Results:

  • Hypertension induces a significant shift in cardiac substrate utilization, favoring increased glucose metabolism.
  • This metabolic shift occurs prior to the development of observable structural changes in the heart.
  • Consistent patterns of altered cardiac metabolism are observed in both human and animal models.

Conclusions:

  • Hypertension fundamentally alters myocardial energy metabolism, promoting glucose reliance.
  • Early metabolic changes in the heart precede structural damage, offering potential therapeutic targets.
  • Understanding these metabolic adaptations is crucial for managing heart failure risk in hypertensive patients.

Keywords:
DOCA-saltFAT/CD36SHRheart metabolismhypertension

More Related Videos

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats07:41

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

Published on: March 1, 2022

3.4K
Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension07:41

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Published on: March 17, 2022

3.4K

Related Concept Videos

What is Metabolism?00:52

What is Metabolism?

Overview
131.5K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
793
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
879
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
392
Anatomy of the Heart01:27

Anatomy of the Heart

The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
119.5K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.9K