[Effect of tranquilizers on lipid peroxidation of biological membranes]

Thirty-seven patients with unstable angina pectoris were treated with prolonged-action nitrates for 20 days; 8 of these received additionally meprobamate in a dose of 0.4 g per day and 11 patients received phenazepam in a dose of 0.002 g per day. The addition of tranquillizers to the complex of treatment led to a significant decrease of one of the final products of biological membrane lipid peroxidation--Schiff's bases in erythrocytic membranes. During treatment with phenazepam a similar decrease was more rapid (by the 5th day of treatment) and more pronounced.