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Obesity-Related Epigenetic Changes After Bariatric Surgery
Andrea G Izquierdo1,2, Ana B Crujeiras1,2
1Epigenomics in Endocrinology and Nutrition Group, Instituto de Investigacion Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela, Spain.
Frontiers in Endocrinology
|May 2, 2019
Summary
Bariatric surgery may reverse obesity-related epigenetic changes, offering potential for personalized treatments. Further research is needed to confirm if epigenetic markers can predict surgical success in managing obesity.
Area of Science:
- Epigenetics
- Metabolic Disorders
- Bariatric Surgery
Background:
- Obesity is linked to environmental factors influencing epigenetic modifications.
- Epigenetic marks may play a role in obesity development and its comorbidities.
- The reversibility of obesity-related epigenetic changes via weight loss interventions is an area of active research.
Purpose of the Study:
- To review the impact of bariatric surgery on epigenetic regulation.
- To determine if epigenetic mechanisms mediate the beneficial effects of bariatric surgery on obesity and related conditions.
Main Methods:
- A comprehensive literature review of PubMed was conducted.
- Keywords included obesity, epigenetics, and bariatric surgery.
- Relevant recent publications were selected for analysis.
Main Results:
- Bariatric surgery has been shown to induce differential DNA methylation and alter non-coding RNA expression.
- Epigenetic regulation may mediate improvements in body weight, insulin resistance, hypertension, and cardiovascular disease post-surgery.
- Current evidence is nascent, highlighting the need for longitudinal studies on epigenetic marker predictability.
Conclusions:
- Bariatric surgery demonstrates potential in partially reversing the obesity-associated epigenome.
- Identifying epigenetic biomarkers could enable personalized therapeutic strategies for severe obesity.
- Further investigation is crucial to establish the predictive value of epigenetic marks for bariatric surgery outcomes.
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