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Dietary Modulation of Intestinal Microbiota: Future Opportunities in Experimental Autoimmune Encephalomyelitis and

Yuying Fan1, Junmei Zhang1

  • 1Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.

Frontiers in Microbiology
|May 2, 2019
PubMed

Insights

Dietary interventions can modify the gut microbiota, influencing multiple sclerosis (MS) development and progression. Altering gut microbes and their metabolites offers a promising strategy for managing MS inflammation.

Area of Science:

  • Neuroimmunology
  • Microbiome Research
  • Gastroenterology

Background:

  • Multiple sclerosis (MS) is a CNS autoimmune disease.
  • Gut microbiota composition is an environmental risk factor for MS and its animal model, EAE.
  • Gut dysbiosis and altered host-microbe interactions impact MS pathophysiology.

Purpose of the Study:

  • To review the role of diet in modulating the gut microbiota for MS treatment and prevention.
  • To explore the connection between gut microbiota, metabolites, and neurological health in MS.
  • To highlight the therapeutic potential of targeting the gut microbiome in MS.

Main Methods:

  • Review of current literature on MS, EAE, gut microbiota, and diet.
  • Analysis of microbial metabolites, such as SCFAs, and their immunomodulatory effects.
  • Examination of host microRNA interactions with the gut microbiome.

Main Results:

  • Gut microbiota alterations are linked to MS development and inflammation.
  • Beneficial microbial metabolites can reduce or prevent MS-related inflammation.
  • Dietary interventions can effectively alter gut microbiota composition and function.

Conclusions:

  • Regulation of the intestinal microbiota is a key strategy for reducing MS inflammation.
  • Dietary modulation of the gut microbiome holds potential for MS prevention and treatment.
  • Targeting gut microbial metabolites and their signaling pathways is crucial for MS management.
Keywords:
dietary habitsexperimental autoimmune encephalomyelitismicroRNAmicrobiotamultiple sclerosisshort-chain fatty acid

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