Superoxide dismutase activity as a predictor of adverse outcomes in patients with nonischemic dilated cardiomyopathy

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Ewa Romuk1, Wojciech Jacheć2, Ewa Kozielska-Nowalany2

  • 1Department of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, Jordana 19 Street, 41-808, Zabrze, Poland. eromuk@gmail.com.

Cell Stress & Chaperones
|May 2, 2019
PubMed

Insights

Elevated superoxide dismutase (SOD) activity in patients with nonischemic dilated cardiomyopathy indicates a poorer prognosis. This finding suggests serum SOD levels can help predict adverse outcomes in heart failure (HF).

Area of Science:

  • Biochemistry
  • Cardiology
  • Biomarkers

Background:

  • Oxidative stress is a key factor in heart failure (HF) progression.
  • Superoxide dismutase (SOD) and its isoenzymes (CuZnSOD, MnSOD) play crucial roles in managing oxidative stress.
  • Identifying reliable prognostic factors in nonischemic dilated cardiomyopathy (NIDCM) is essential for patient management.

Purpose of the Study:

  • To evaluate the efficacy of total SOD, CuZnSOD, and MnSOD activities as prognostic factors in NIDCM.
  • To assess the predictive value of SOD isoenzyme activities for long-term clinical outcomes in NIDCM patients.
  • To determine if serum SOD activity can serve as a predictor of adverse outcomes in HF.

Main Methods:

  • A 5-year follow-up study involving 109 patients with NIDCM.
  • Measurement of total SOD, MnSOD, and CuZnSOD activities.
  • Analysis of clinical, echocardiographic, and laboratory parameters, including NT-proBNP, hemoglobin, sodium, creatinine clearance, left ventricular ejection fraction (LVEF), BMI, and NYHA class.
  • Regression analysis to identify predictors of long-term clinical outcomes (death, heart transplant, combined endpoint).

Main Results:

  • Total serum SOD activity was a significant predictor of worse long-term clinical outcomes, independent of NT-proBNP, hemoglobin, sodium, creatinine clearance, LVEF, BMI, and NYHA class.
  • MnSOD and CuZnSOD activities also predicted worse outcomes, though statistical significance was borderline after adjustment for LVEF.
  • Increased activities of total SOD and its isoenzymes in NIDCM patients correlated with poor prognosis.

Conclusions:

  • Elevated serum SOD activity and its isoenzymes (MnSOD, CuZnSOD) in NIDCM patients are associated with a poor prognosis.
  • Serum SOD activity may serve as a valuable and independent predictor of adverse clinical outcomes in patients with heart failure.
  • These findings highlight the prognostic utility of assessing oxidative stress markers in NIDCM.

Keywords:
Dilated cardiomyopathyHeart failureOxidative stressSuperoxide dismutase

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