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Related Experiment Video

Updated: Jan 25, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Thrombotic Complications in Gliomas.

Alexandra L Czap¹, Ashley Becker¹, Patrick Y Wen²

¹Department of Neurology, University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas.

Seminars in Thrombosis and Hemostasis

|May 2, 2019

Summary

Glioma patients frequently experience arterial and venous thromboses due to hypercoagulability. Anticoagulation, particularly low molecular weight heparin, is safe and effective for managing these thrombotic events in glioma patients.

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Area of Science:

Neuro-oncology
Hematology
Vascular Medicine

Background:

Arterial and venous thromboses are prevalent in glioma patients, occurring perioperatively and during disease progression.
High-grade gliomas are associated with hypercoagulability, increasing thrombotic risk due to immobility and neurological deficits.

Purpose of the Study:

To review the epidemiology, risk factors, and management strategies for thrombotic complications in glioma patients.
To address the lack of standardized management approaches and historical concerns regarding anticoagulation.

Main Methods:

Literature review focusing on studies investigating thrombotic events in glioma patients.
Analysis of historical practices and current evidence regarding anticoagulation safety and efficacy.

Main Results:

Multiple studies confirm the safety and efficacy of anticoagulation in indicated glioma patients.
Low molecular weight heparin is identified as a preferred treatment for short- and long-term anticoagulation.

Conclusions:

Despite historical concerns about hemorrhage, anticoagulation is a viable and effective strategy for managing thrombosis in glioma.
Standardized management protocols are needed to optimize care for glioma patients at risk of thrombotic events.