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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Cancer Prevention02:59

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Area of Science:

  • Oncology
  • Hematology
  • Pathophysiology

Background:

  • Thrombotic microangiopathy (TMA) is a serious condition linked to cancer and its treatments.
  • TMA is characterized by low platelet counts, hemolytic anemia, and organ damage.
  • This review focuses specifically on TMA causes related to cancer and its therapies.

Purpose of the Study:

  • To review the pathophysiology of cancer-related TMA.
  • To discuss TMA associated with chemotherapy and transplantation.
  • To explore emerging therapeutic options for TMA in cancer patients.

Main Methods:

  • Literature review of cancer-associated TMA.
  • Analysis of pathophysiology, chemotherapy-induced TMA, and transplant-related TMA.
  • Examination of current and novel treatment strategies.

Main Results:

  • Cancer and its treatments are significant causes of TMA.
  • Chemotherapy and stem cell transplantation are key triggers for TMA.
  • Understanding the pathophysiology is crucial for managing TMA.

Conclusions:

  • Cancer-associated TMA requires specific attention due to its complexity.
  • Further research into novel therapeutics is essential for improving patient outcomes.
  • Early recognition and management of TMA are critical in oncology settings.