Related Experiment Video
Updated: Jan 25, 2026

Fast and Accurate Exhaled Breath Ammonia Measurement
Published on: June 11, 2014
Fast and accurate relatedness estimation from high-throughput sequencing data in the presence of inbreeding
Kristian Hanghøj1,2, Ida Moltke3, Philip Alstrup Andersen3
1Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen K, Denmark.
Background:
The estimation of relatedness between pairs of possibly inbred individuals from high-throughput sequencing (HTS) data has previously not been possible for samples where we cannot obtain reliable genotype calls, as in the case of low-coverage data.
Results:
We introduce ngsRelateV2, a major revision of ngsRelateV1, a program that originally allowed for estimation of relatedness from HTS data among non-inbred individuals only. The new revised version takes into account the possibility of individuals being inbred by estimating the 9 condensed Jacquard coefficients along with various other relatedness statistics. The program is threaded and scales linearly with the number of cores allocated to the process.
Conclusion:
The program is available as an open source C/C++ program under the GPL license and hosted at https://github.com/ANGSD/ngsRelate. To facilitate easy analysis, the program is able to work directly on the most commonly used container formats for raw sequence (BAM/CRAM) and summary data (VCF/BCF).
Related Concept Videos
What are Estimates?
The estimate for the mean of a sample is denoted by ͞x, whereas the mean of the population is designated as μ. Further, parameters such...
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Data Reporting and Recording
Estimation of k and VD of Aminoglycosides
Fast Fourier Transform
The computational efficiency of the FFT becomes...
Cis-regulatory Sequences

