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FCRL5+ Memory B Cells Exhibit Robust Recall Responses
Charles C Kim1, Alyssa M Baccarella1, Aqieda Bayat1
1Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Cell Reports
|May 3, 2019
Summary
FCRL5-expressing atypical memory B cells (atMBCs) are found in chronic infections and expand during malaria. This study shows these cells are functional and suggests targeting them for vaccine development.
Area of Science:
- Immunology
- Infectious Diseases
- Vaccinology
Background:
- Atypical memory B cells (atMBCs) expressing FCRL5 are implicated in chronic infections like malaria, but their function remains debated.
- Previous studies have yielded conflicting conclusions regarding the role and origin of FCRL5+ B cells.
Purpose of the Study:
- To investigate the function and phenotype of FCRL5+ B cells in a murine model of Plasmodium chabaudi infection.
- To compare murine FCRL5+ B cells with human atypical memory B cells (atMBCs) found in malaria-exposed individuals.
- To determine if the atypical B cell phenotype is exclusive to chronic infections.
Main Methods:
- Induction of Plasmodium chabaudi infection in mice.
- Phenotypic and transcriptomic analysis of FCRL5+ B cells.
- Comparative analysis of B cells from infected mice and malaria-exposed humans.
- Immunization studies in mice and humans.
Main Results:
- Expansion of a distinct, antigen-specific FCRL5+ B cell population in Plasmodium-infected mice.
- Phenotypic and transcriptomic similarities between murine FCRL5+ B cells and human atMBCs.
- FCRL5+ memory B cells in infected mice rapidly differentiate into antibody-producing cells in vivo.
- Atypical markers are present on antigen-specific memory B cells post-immunization in both mice and humans.
Conclusions:
- FCRL5+ B cells are functional and arise from germinal-center-derived memory B cells.
- The atypical B cell phenotype is not restricted to chronic infections but also occurs after immunization.
- FCRL5+ B cells represent a promising target for developing novel vaccine strategies.
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