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Related Experiment Video

Updated: Jan 25, 2026

Anterior Cervical Discectomy and Fusion in the Ovine Model

Anterior Cervical Discectomy and Fusion in the Ovine Model

Published on: October 5, 2009

Molecular testing and cervical screening: will one test fit all?

Erin McCarthy¹, Changhong Ye¹, Michele Smith¹

¹Section of Cytology, Disease Prevention Division, University of Wisconsin State Laboratory of Hygiene, Madison, Wisconsin.

Journal of the American Society of Cytopathology

|May 3, 2019

Summary

Molecular human papillomavirus (HPV) testing for cervical cancer screening missed nearly 60% of high-grade cases. Further research is needed to ensure effective HPV screening for all women.

Keywords:

Cervical screening Cobas4800 HPV test performance HPV testing Papanicolaou test Public health

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Published on: April 7, 2015

Area of Science:

Gynecology
Oncology
Public Health

Background:

Cervical screening practices are evolving, with molecular human papillomavirus (HPV) testing for HPV 16/18 becoming standard.
Questions remain about the effectiveness of molecular versus morphologic testing and its applicability across diverse populations.
A public health laboratory serving underserved populations highlights the need to address these screening considerations.

Purpose of the Study:

To evaluate the concordance of Papanicolaou (Pap) test results with HPV testing in a high-risk, underserved population.
To determine if current HPV testing protocols adequately identify high-grade cervical abnormalities in this demographic.
To assess the prevalence of non-HPV 16/18 genotypes in high-grade Pap cases.

Main Methods:

Retrospective review of 20,211 cytology tests from July 2013 to May 2015.
Focused analysis on 521 high-grade Pap diagnoses, with concurrent HPV testing on 387 cases using the cobas 4800 HPV test.
Secondary HPV testing via PCR on 205 residual samples negative for HPV 16/18 by cobas.

Main Results:

Of 387 high-grade Pap cases with concurrent HPV testing, 58% (225) were negative for HPV 16/18.
No HPV was detected in 14% (55) of these high-grade cases.
Secondary testing identified 25 different HPV genotypes in the evaluated samples.

Conclusions:

The high rate of high-grade Pap results negative for HPV 16/18 is concerning for current cervical screening protocols.
Findings suggest that molecular HPV testing, particularly targeting only HPV 16/18, may not be sufficient for comprehensive cervical screening in all populations.
Further investigation is crucial to ensure the quality and integrity of women's health services as screening evolves.