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Updated: Jan 25, 2026

Using Primary Neurosphere Cultures to Study Primary Cilia
Published on: April 14, 2017
Interplay Between Primary Cilia and Autophagy and Its Controversial Roles in Cancer
Je Yeong Ko1, Eun Ji Lee1, Jong Hoon Park1
1Department of Life Systems, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Abstract:
Primary cilia and autophagy are two distinct nutrient-sensing machineries required for maintaining intracellular energy homeostasis, either via signal transduction or recycling of macromolecules from cargo breakdown, respectively. Potential correlations between primary cilia and autophagy have been recently suggested and their relationship may increase our understanding of the pathogenesis of human diseases, including ciliopathies and cancer. In this review, we cover the current issues concerning the bidirectional interaction between primary cilia and autophagy and discuss its role in cancer with cilia defect.
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