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Updated: Jan 25, 2026

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Published on: March 19, 2013

Engineering complex muscle-tissue interfaces through microfabrication.

Chiara Arrigoni¹, Dalila Petta¹, Simone Bersini²

¹Regenerative Medicine Technologies Lab, Ente Ospedaliero Cantonale (EOC), Via Tesserete 46, 6900 Lugano, Switzerland.

|May 3, 2019

Summary

This summary is machine-generated.

Advanced biofabrication and microfluidics create better skeletal muscle models. These techniques better mimic muscle interfaces, improving functionality for studying muscle diseases and aging.

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Experimental Approaches to Tissue Engineering

Experimental Approaches to Tissue Engineering

Published on: August 30, 2007

Area of Science:

Biomedical Engineering
Tissue Engineering
Cell Biology

Background:

Skeletal muscle's complex architecture is crucial for function, involving neural, vascular, and connective tissue interfaces.
Pathological conditions and physiological changes alter muscle structure and function.
Existing in vivo and in vitro models have limitations in replicating muscle microarchitecture and environment.

Purpose of the Study:

To critically review microfluidics and biofabrication for modeling skeletal muscle interfaces.
To discuss the role of these techniques in creating models of neural, vascular, and tendon connections.
To assess the progress and limitations in replicating muscle tissue interfaces.

Main Methods:

Review of microfluidics applications in skeletal muscle modeling.
Review of biofabrication techniques for skeletal muscle constructs.
Analysis of combined microfluidics and biofabrication strategies.

Main Results:

Microfluidics and biofabrication individually improve spatial organization and functionality of muscle models.
These techniques show promise in mimicking complex muscle interfaces.
Current models still struggle to fully replicate architecture, protein presence, and signaling pathways.

Conclusions:

Integrating microfluidics and biofabrication offers higher resolution patterning for complex muscle structures.
Further development is needed to fully recapitulate skeletal muscle interfaces and their functions.
These advanced models are key for studying skeletal muscle in health and disease.