Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does interstitial lung edema compress airways and arteries? A morphometric study.

R P Michel, L Zocchi, A Rossi

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |January 1, 1987
    PubMed
    Summary

    Interstitial edema does not compress small airways or arteries. Other mechanisms, like alveolar and airway luminal edema, may cause increased airway resistance in lung edema.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mitomycin C and vindesine: an ineffective combination chemotherapy in the treatment of malignant pleural mesothelioma.

    Tumori·1992
    Same author

    Neoadjuvant chemotherapy with cisplatin, epirubicin and VP-16 for stage IIIA-IIIB non-small-cell lung cancer: a pilot study.

    Tumori·1992
    Same author

    Supraspinal influences on recurrent inhibition in humans. Paralysis of descending control of Renshaw cells in patients with mental retardation.

    Electroencephalography and clinical neurophysiology·1992
    Same author

    Expression in murine and human neuroblastoma cell lines of VGF, a tissue specific protein.

    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·1992
    Same author

    Calcium entry blockade as a mechanism for chlordimeform-induced inhibition of motor activity in the isolated guinea-pig ileum.

    Pharmacology & toxicology·1992
    Same author

    Energy metabolism of the hypertrophied heart studied by 31P nuclear magnetic resonance.

    Cardioscience·1992

    Area of Science:

    • Pulmonary physiology
    • Respiratory system mechanics
    • Pathology of lung edema

    Background:

    • Lung edema, characterized by excess fluid in lung tissues, can affect airway resistance.
    • Understanding the structural changes in small airways and vessels during edema is crucial for explaining altered respiratory function.

    Purpose of the Study:

    • To investigate the impact of hydrostatic and increased permeability edema on the dimensions of small airways and arteries.
    • To determine if interstitial edema causes compression of small airways and pulmonary arteries.
    • To explore potential mechanisms contributing to increased airway resistance in edematous lungs.

    Main Methods:

    • Comparison of airway and arterial areas/diameters in control, hydrostatic edema, and increased permeability edema groups of dogs using quantitative histology.

    Related Experiment Videos

  • Measurement of pulmonary pressures and cardiac output.
  • Assessment of extravascular lung water and grading of alveolar and airway luminal edema.

    • Main Results:

    • Hydrostatic edema increased pulmonary arterial and wedge pressures, while vascular resistance decreased.
    • Extravascular lung water was significantly elevated in both hydrostatic and increased permeability edema groups compared to controls.
    • Quantitative histology revealed no decrease in airway or arterial areas/diameters; they increased with transpulmonary pressure, and air-space edema was observed.

    Conclusions:

    • Interstitial lung edema does not appear to compress small airways or pulmonary arteries.
    • Alveolar and airway luminal edema are likely contributors to the increased airway resistance observed in lung edema.
    • Further research is needed to elucidate the precise mechanisms of airway obstruction in edematous lungs.