Related Experiment Video
Updated: Jan 25, 2026

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
Published on: September 15, 2023
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)
Amy G Zhou1, Justin A Bishop1, Syed Z Ali2
1Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Abstract:
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a new term replacing what was previously known as non-invasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC). These tumors show benign/indolent clinical behavior when compared with invasive FVPTC, which led to their reclassification as a "non-malignant" neoplasm. NIFTP shares essentially similar cytomorphologic features as FVPTC, and can only be definitively diagnosed on surgical excision specimens. This article provides an update on morphologic characteristics of NIFTP, along with pertinent molecular studies and management algorithms.
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