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Circulating microparticle subpopulation in metabolic syndrome: relation to oxidative stress and coagulation markers

Asmaa M Zahran1, Sohair K Sayed2, Heba A Abd El Hafeez2

  • 1Department of Clinical Pathology, South Egypt Cancer Institute, Assiut, Egypt.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|May 3, 2019
PubMed
Abstract

Insights

Circulating microparticles (MPs) are elevated in metabolic syndrome (MetS), correlating with oxidative stress and coagulation markers. These findings suggest MPs may predict early MetS and cardiovascular disease risk.

Area of Science:

  • Cardiovascular Research
  • Metabolic Syndrome Studies
  • Biomarker Discovery

Background:

  • Circulating microparticles (MPs) are implicated in atherothrombotic disorders and elevated in cardiovascular diseases.
  • Metabolic syndrome (MetS) is characterized by moderate metabolic abnormalities.
  • Early detection of MetS and associated risks is crucial for cardiovascular health.

Purpose of the Study:

  • To investigate the impact of early-stage MetS on circulating MP subpopulations.
  • To examine the relationship between MP subpopulations and oxidative stress markers.
  • To explore associations between MP subpopulations and coagulation factors.

Main Methods:

  • Flow cytometry was employed to analyze circulating MP subpopulations in MetS patients and healthy controls.
  • Enzyme-linked immunosorbent assay (ELISA) quantified plasminogen activator inhibitor type 1/tissue plasminogen activator (PAI-1/TPA).
  • Plasma glutathione peroxidase (GPx) activity was measured spectrophotometrically.

Main Results:

  • Total MPs were significantly higher in MetS patients (P<0.001).
  • Glutathione peroxidase and PAI-1/TPA activity were significantly increased in MetS subjects (P<0.001).
  • MetS parameters like waist circumference, blood pressure, and cholesterol levels correlated with MP levels and coagulation factors.

Conclusions:

  • Elevated circulating MPs are linked to MetS, oxidative stress, and coagulation abnormalities.
  • MP subpopulations may serve as early predictors for MetS.
  • These findings highlight the potential of MPs in assessing cardiovascular disease risk in MetS patients.
Keywords:
CVDcirculating microparticlescoagulationmetabolic syndromeoxidative stress

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