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Retinal sensitivity in angioid streaks.

Yoko Nomura1, Tatsuya Inoue1, Shotaro Asano1

  • 1Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|May 3, 2019
PubMed
Summary

Eyes with angioid streaks (AS) show significant outer retinal and retinal pigment epithelium (RPE) atrophy. Retinal sensitivity is reduced in atrophic areas, particularly in those with reticular pseudodrusen (RPD).

Keywords:
Angioid streaksOuter retinal atrophyRetinal pigment epithelium atrophyRetinal sensitivity

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Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Visual Function

Background:

  • Angioid streaks (AS) are a condition affecting the choroid and retinal pigment epithelium (RPE).
  • Understanding the impact of AS on retinal sensitivity is crucial for patient management.

Purpose of the Study:

  • To investigate retinal sensitivity in eyes diagnosed with angioid streaks (AS).
  • To assess the relationship between atrophy in the RPE and outer retina and visual function in AS.

Main Methods:

  • Retrospective observational case series of 13 eyes from 9 patients with AS.
  • Ophthalmologic examination included fundus autofluorescence (FAF), spectral domain optical coherence tomography (SD-OCT), and microperimetry.
  • Assessment of RPE atrophy, outer retinal atrophy (ellipsoid zone disruption), and their association with retinal sensitivity.

Main Results:

  • Outer retinal atrophy areas were significantly larger than RPE atrophy areas (14.5 mm² vs 9.0 mm²).
  • Retinal sensitivity was markedly reduced in areas of RPE atrophy (2.4 dB) and outer retinal atrophy (14.6 dB) compared to healthy areas (25.6 dB).
  • Eyes with reticular pseudodrusen (RPD) exhibited more extensive atrophy and greater sensitivity loss.

Conclusions:

  • Eyes with AS frequently present with extensive outer retinal and RPE atrophy.
  • Retinal sensitivity is significantly diminished in these atrophic regions.
  • The presence of RPD exacerbates atrophy and visual function impairment in AS.