Multi-pass approach to reduce cone-beam artifacts in a circular orbit cone-beam CT system

We propose a multi-pass approach to reduce cone-beam artifacts in a circular orbit cone-beam computed tomography (CT) system. Employing a large 2D detector array reduces the scan time but produces cone-beam artifacts in the Feldkamp, Davis, and Kress (FDK) reconstruction because of insufficient sampling for exact reconstruction. While the two-pass algorithm proposed by Hsieh is effective at reducing cone-beam artifacts, the correction performance is degraded when the bone density is moderate and the cone angle is large. In this work, we treated the cone-beam artifacts generated from bone and soft tissue as if they were from less dense bone objects and corrected them iteratively. The proposed method was validated using a numerical Defrise phantom, XCAT phantom data, and experimental data from a pediatric phantom followed by image quality assessment for FDK, the two-pass algorithm, the proposed method, and the total variation minimization-based iterative reconstruction (TV-IR). The results show that the proposed method was superior to the two-pass algorithm in cone-beam artifact reduction and effectively reduced the overcorrection by the two-pass algorithm near bone regions. It can also be observed that the proposed method produced better correction performance with fewer iterations than the TV-IR algorithm. A qualitative evaluation with mean-squared error, structural similarity, and structural dissimilarity demonstrated the effectiveness of the proposed method.