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Related Concept Videos

Structural Protein Function01:56

Structural Protein Function

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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
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Protein and Protein Structure02:15

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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Mechanical Protein Functions01:58

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Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
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Short-distance Transport of Resources02:12

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Short-distance transport refers to transport that occurs over a distance of just 2-3 cells, crossing the plasma membrane in the process. Small uncharged molecules, such as oxygen, carbon dioxide, and water, can diffuse across the plasma membrane on their own. In contrast, ions and larger molecules require the assistance of transport proteins due to their charge or size. Transport across membranes also occurs within individual cells, playing a variety of essential roles for the plant as a whole.
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Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
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Updated: Jan 25, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
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A Protocol for Computer-Based Protein Structure and Function Prediction

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IntFOLD: an integrated web resource for high performance protein structure and function prediction.

Liam J McGuffin1, Recep Adiyaman1, Ali H A Maghrabi1

  • 1School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AS, UK.

Nucleic Acids Research
|May 3, 2019
PubMed
Summary
This summary is machine-generated.

The IntFOLD server now offers enhanced protein structure prediction and analysis tools. Updates improve accuracy, visualization, and user-friendliness for protein tertiary structure, domain boundaries, and interactions.

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Area of Science:

  • Structural biology
  • Bioinformatics
  • Computational biology

Background:

  • The IntFOLD server is a key resource for automated protein structure prediction.
  • Previous versions have been validated through CASP and CAMEO evaluations.
  • Independent metrics confirm IntFOLD as a top-performing server.

Purpose of the Study:

  • To detail significant updates to the IntFOLD server.
  • To enhance performance in protein tertiary structure prediction and accuracy self-estimation.
  • To improve the user interface and add new functionalities.

Main Methods:

  • Upgraded server back end with the ModFOLD7_rank algorithm for improved tertiary structure predictions.
  • Enhanced front-end features including streamlined submission and visualization.
  • Implemented new confidence scores and model refinement options.

Main Results:

  • Achieved performance improvements in global 3D model quality and accuracy self-estimates (ASE).
  • Introduced a more intuitive user experience with enhanced visualization and data access.
  • Added functionality for users to submit models for further refinement.

Conclusions:

  • The updated IntFOLD server provides a more powerful and user-friendly resource for protein structure prediction and analysis.
  • Performance enhancements and new features solidify IntFOLD's position as a leading bioinformatics tool.
  • The server facilitates deeper insights into protein structure, function, and interactions.