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Updated: Jul 4, 2026

Correlative Light- and Electron Microscopy Using Quantum Dot Nanoparticles
11:16

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Published on: August 7, 2016

Tumor cell pH detection based on CdSe quantum dots' fluorescence charateristics.

Quan Liu, Chao Zheng, Hui Zhao

    Technology and Health Care : Official Journal of the European Society for Engineering and Medicine
    |May 3, 2019
    PubMed
    Summary

    This study introduces a novel pH detection method using cadmium selenide (CdSe) quantum dots for early cancer diagnosis. The technique offers high resolution and stability, presenting a promising advancement in cancer detection technologies.

    Keywords:
    CdSe quantum dotsTumor cellsfluorescence characteristicspH value of cell metabolites

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    Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

    Published on: October 13, 2023

    Area of Science:

    • Biomedical Engineering
    • Materials Science
    • Analytical Chemistry

    Background:

    • Cancer incidence is rising, necessitating early diagnosis and effective monitoring.
    • Tumor cell metabolism causes extracellular environment acidification, a key cancer characteristic.
    • Accurate and efficient pH measurement is crucial for cancer detection and research.

    Purpose of the Study:

    • To develop a novel, highly sensitive pH detection method for biological samples.
    • To utilize the unique fluorescence properties of cadmium selenide (CdSe) quantum dots (QDs) for pH sensing.
    • To establish a reliable method for monitoring the acidic microenvironment of cancer cells.

    Main Methods:

    • Employing CdSe quantum dots as fluorescent probes for pH detection.
    • Utilizing a 365 nm laser source for excitation of CdSe QDs in phosphate-buffered saline (PBS) solutions.
    • Developing a mathematical model correlating fluorescence intensity with pH values.
    • Simulating physiological conditions using 0.2 mol/L PBS buffer at varying pH levels.

    Main Results:

    • A robust mathematical model was established linking fluorescence intensity to pH.
    • The method demonstrated superior effectiveness compared to existing pH detection techniques.
    • Achieved high resolution of 0.037 pH units within the critical pH range of 6.1–7.8.
    • Exhibited excellent temperature stability and rapid measurement times.

    Conclusions:

    • The developed CdSe QD-based fluorescence method offers a highly sensitive and stable approach for pH detection.
    • This technique presents a significant advancement with high potential for application in early cancer diagnosis.
    • The study highlights a novel and superior strategy for generalizing pH detection in various scientific fields.