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H2S attenuates the myocardial fibrosis in diabetic rats through modulating PKC-ERK1/2MAPK signaling pathway

Junrong Long1,1, Maojun Liu1, Shengquan Liu1

  • 1Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.

Technology and Health Care : Official Journal of the European Society for Engineering and Medicine
|May 3, 2019
PubMed

Insights

Exogenous hydrogen sulfide (H2S) effectively reduces myocardial fibrosis in diabetic rats. This protective effect is linked to regulating specific signaling pathways and reducing inflammation.

Area of Science:

  • Cardiovascular Research
  • Diabetology
  • Biochemistry

Background:

  • Diabetic cardiomyopathy is characterized by myocardial fibrosis.
  • Understanding mechanisms to treat diabetic complications is crucial.

Purpose of the Study:

  • Investigate exogenous hydrogen sulfide's role in attenuating diabetic myocardial fibrosis.
  • Elucidate the underlying molecular mechanisms.

Main Methods:

  • Streptozotocin-induced diabetic rat model.
  • Administration of exogenous hydrogen sulfide (NaHS).
  • Assessment of myocardial collagen deposition and protein expression via Masson staining and Western blotting.

Main Results:

  • Diabetic rats showed increased collagen deposition and pro-fibrotic protein expression.
  • Exogenous H2S significantly attenuated collagen deposition and modulated protein expression.
  • PPAR gamma expression was upregulated by H2S treatment.

Conclusions:

  • Exogenous H2S effectively attenuates myocardial fibrosis in diabetic rats.
  • Potential mechanisms involve regulating the PKC-ERK1/2MAPK signaling pathway.
  • H2S may improve MMPs/TIMPs dysregulation and inhibit inflammatory responses.
Keywords:
DM ratsERK1/ 2mitogen-activated protein kinaseExogenous hydrogen sulfideMMPs/TIMPs expression dysregulationinflammatory reactionmyocardial fibrosisprotein kinase C

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