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Successful Treatment of an EBV-positive Diffuse Large B-Cell Lymphoma in a Patient With Trisomy 21

Maria C Putti1, Antonio Marzollo1, Elisa Carraro1

  • 1Department of Women's and Children's Health, Pediatric Hematology-Oncology Unit, University of Padova.

Journal of Pediatric Hematology/Oncology
|May 3, 2019
PubMed

Diffuse large B-cell Lymphoma (DLBCL) secondary to a chronic severe Epstein-Barr virus (EBV) infection has not been previously described in a patient with trisomy 21. Here we report the case of a 14-year-old girl with trisomy 21 with impaired control of EBV and DLBCL. She was cured with dose-adapted chemotherapy and hematopoietic stem cell transplantation without severe treatment-related toxicity. We describe the first case of EBV-positive DLBCL in a patient with trisomy 21 and we propose a treatment modality for this rare entity.

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