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Immunoglobulin-producing cells in human odontogenic cysts
Journal of Oral Pathology
|January 1, 1987
Summary
Immunohistochemistry revealed immunoglobulin G (IgG) plasma cells dominate odontogenic keratocysts and other dental cysts. Differences in IgG, IgA, and IgM plasma cell percentages were statistically significant between cyst types.
Area of Science:
- Oral pathology
- Immunology
- Histology
Background:
- Odontogenic cysts are common jaw lesions.
- Understanding the inflammatory infiltrate, particularly plasma cells, is crucial for diagnosis and management.
- Immunoglobulin (Ig) profiles can vary between different cyst types.
Purpose of the Study:
- To investigate and compare the types and distribution of immunoglobulin-containing plasma cells in odontogenic keratocysts, dental (periapical) cysts, and dentigerous cysts.
- To identify potential differences in plasma cell populations that may aid in cyst characterization.
Main Methods:
- Immunohistochemical staining was employed to identify and quantify plasma cells expressing IgG, IgA, and IgM.
- Staining was performed on tissue samples from odontogenic keratocysts, dental (periapical) cysts, and dentigerous cysts.
- Statistical analysis was used to compare the percentage contributions of different Ig-containing plasma cells between the cyst types.
Main Results:
- Immunoglobulin G (IgG)-containing plasma cells were the predominant type in all examined cyst categories.
- Significantly lower percentages of IgA and few IgM-containing plasma cells were observed across all cyst types.
- Statistically significant differences in the proportions of IgG and IgA plasma cells were noted between keratocysts and both periapical and dentigerous cysts.
- A significant difference in IgM plasma cell percentage was found between keratocysts and periapical cysts.
- Intense extracellular IgG staining was a consistent finding in all cyst types.
Conclusions:
- Immunoglobulin G plasma cells are the primary immunoglobulin-producing cells in odontogenic keratocysts, dental (periapical) cysts, and dentigerous cysts.
- Distinct differences in plasma cell populations exist between odontogenic keratocysts and other common cyst types, suggesting potential diagnostic value.
- The consistent extracellular IgG staining warrants further investigation into its role in cyst pathogenesis.