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Nasal colonization with methicillin-resistant Staphylococcus aureus associated with elevated homocysteine levels in

Kyoung-Bok Min1, Jin-Young Min2

  • 1Department of Preventive Medicine, Seoul National University College of Medicine.

Medicine
|May 3, 2019
PubMed

Insights

Higher serum homocysteine levels are linked to increased risk of nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) in US adults. This finding may help in developing strategies to prevent MRSA infections.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) presents a significant global health challenge.
  • Understanding risk factors for MRSA colonization is crucial for effective prevention strategies.

Purpose of the Study:

  • To investigate the association between serum homocysteine levels and nasal colonization with Staphylococcus aureus and MRSA in US adults.
  • To identify potential biomarkers for MRSA carriage in the general population.

Main Methods:

  • Cross-sectional analysis of a nationally representative sample of 7832 US adults (≥20 years).
  • Serum homocysteine levels were analyzed across quartiles.
  • Nasal colonization with S. aureus and MRSA was determined by culture.

Main Results:

  • 26.2% of subjects were culture-positive for S. aureus, with 4.8% colonized by MRSA.
  • Higher serum homocysteine levels were significantly associated with increased odds of MRSA nasal colonization (OR, 3.09; 95% CI, 1.11-8.61).
  • No significant association was found between homocysteine levels and S. aureus (non-MRSA) colonization.

Conclusions:

  • Elevated serum homocysteine is significantly associated with nasal MRSA colonization in the US general community.
  • Homocysteine may serve as a potential indicator for MRSA carriage.
  • Further research is warranted to explore the mechanisms underlying this association and its clinical implications.

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