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Child and adolescent chronic fatigue syndrome/myalgic encephalomyelitis: where are we now?

Anna Gregorowski1, Jane Simpson2, Terry Y Segal1

  • 1Paediatric and Adolescent Department, University College Hospital, University College London Hospitals NHS Foundation Trust.

Current Opinion in Pediatrics
|May 3, 2019
PubMed

Insights

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in children and young people presents a complex challenge with limited evidence for effective treatments. Further research is crucial to understand causes and improve care for this debilitating condition.

Area of Science:

  • Pediatric Health
  • Neurology
  • Immunology

Background:

  • Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a debilitating illness affecting children and young people (CYP).
  • The exact cause of CFS/ME remains unclear, presenting a heterogeneous clinical picture.
  • The condition significantly impacts the affected CYP and their families, with comorbidities like mood disorders and pain.

Purpose of the Study:

  • To review recent evidence on the cause, impact, treatment, and prognosis of CFS/ME in CYP.
  • To inform ongoing guideline reviews and identify research needs.
  • To synthesize current knowledge amidst evolving research calls.

Main Methods:

  • Comprehensive literature review of recent evidence.
  • Analysis of studies on CFS/ME in children and young people.
  • Discussion of aetiological hypotheses and precipitating factors.

Main Results:

  • Evidence for effective CFS/ME treatment in CYP is limited, especially for severely affected individuals.
  • Online cognitive behavioral therapy trials are underway for teenagers.
  • The Lightning Process, as an adjunct to medical care, shows effectiveness.

Conclusions:

  • Current evidence is limited by diagnostic heterogeneity and small studies.
  • There is a significant need for more research and larger studies.
  • Further investigation into the causes and optimal treatments for pediatric CFS/ME is essential.
Abstract

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