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Combining low-dose atropine with bifocal contact lenses for myopia control showed good compliance. Two weeks of treatment slightly reduced low-contrast vision but was well-tolerated by young subjects.

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Area of Science:

  • Ophthalmology
  • Optometry
  • Pediatric Eye Care

Background:

  • Myopia progression is a growing concern in children.
  • Controlling myopia progression is crucial to prevent future visual impairment.
  • Combination therapies offer potential for enhanced myopia control.

Purpose of the Study:

  • To evaluate the short-term effects of combining 0.01% atropine with +2.50-diopter add center-distance soft bifocal contact lenses (SBCL) for myopia control.
  • To assess subject characteristics, visual acuity, and vision-related outcomes.
  • To determine the feasibility and tolerability of this combined treatment approach.

Main Methods:

  • The Bifocal & Atropine in Myopia (BAM) study enrolled 49 subjects (mean age 9.6 years) with myopia.
  • Subjects underwent a 2-week trial of the combination treatment.
  • Outcome measures included visual acuity (VA), near phoria, accommodative lag, and pupil size. Compliance was monitored via surveys.

Main Results:

  • After 2 weeks, low-contrast distance VA decreased significantly (P < .0001), while high-contrast VA remained unaffected.
  • Near phoria showed a slight increase in the exo direction (P = .01), with no significant changes in accommodative lag or pupil size.
  • Subject compliance was high (77% wear time for SBCL) and atropine use was consistent (6.4 days/week).

Conclusions:

  • Short-term use of combined 0.01% atropine and +2.50-diopter SBCL resulted in a slight reduction in low-contrast distance VA and a minor increase in near exophoria.
  • The combination treatment was well-tolerated and demonstrated good compliance in young myopic subjects.
  • Further research is warranted to assess the long-term efficacy of this combined therapy for myopia control.