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Bidirectional relationship between transient ischemic attacks and depression: A review

Chanchal K Kahlon1, Henry A Nasrallah

  • 1Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School of Medicine, Monteleone Hall, St. Louis, MO 63104 USA.

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists
|May 3, 2019
PubMed

Insights

Transient ischemic attacks (TIAs) and depression share a bidirectional relationship. Studies show depression increases TIA risk, while TIAs elevate the likelihood of developing depression.

Area of Science:

  • Neurology
  • Psychiatry
  • Epidemiology

Background:

  • Cerebrovascular events and psychiatric disorders are linked, but research often overlooks transient ischemic attacks (TIAs).
  • The relationship between TIAs and depression specifically lacks comprehensive investigation.

Purpose of the Study:

  • To review existing literature on the bidirectional association between TIAs and depression.
  • To determine the risk of depression following TIAs and the risk of TIAs in individuals with depression.

Main Methods:

  • Systematic review of 8 studies.
  • Four studies analyzed depression incidence post-TIA.
  • Four studies analyzed TIA incidence in patients with depression.

Main Results:

  • A bidirectional relationship was observed.
  • 3 of 4 studies indicated an increased TIA risk in depressed patients.
  • 4 of 4 studies found an increased incidence of depression after TIAs (6.88% incidence).

Conclusions:

  • Depression and TIAs exhibit a significant bidirectional relationship.
  • Both conditions are serious and warrant further investigation.
  • Future clinical and neurobiological research is recommended.
Abstract

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