Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statistical properties of molecular tree construction methods under the neutral mutation model.

Y Tateno, F Tajima

    Journal of Molecular Evolution
    |January 1, 1986
    PubMed
    Summary

    The modified Farris method offers the best accuracy for constructing molecular phylogenetic trees, especially when using data from two genes. Uncritical acceptance of published trees can lead to errors due to statistical variation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of Interferon-α on Patients with Previously Untreated Chronic Myelogenous Leukemia in the Early Chronic Phase: Comparison between Interferon-α Continued Patients and Interferon-α Discontinued Patients.

    Hematology (Amsterdam, Netherlands)·2016
    Same author

    Hot water immersion induces an acute cytokine response in cervical spinal cord injury.

    European journal of applied physiology·2015
    Same author

    Elevation of interleukin-6 and attenuation of tumor necrosis factor-α during wheelchair half marathon in athletes with cervical spinal cord injuries.

    Spinal cord·2014
    Same author

    Increase in interleukin-6 immediately after wheelchair basketball games in persons with spinal cord injury: preliminary report.

    Spinal cord·2013
    Same author

    Wheelchair half-marathon race increases natural killer cell activity in persons with cervical spinal cord injury.

    Spinal cord·2012
    Same author

    Effect of age on bowel management in traumatic central cord syndrome.

    Spinal cord·2011

    Area of Science:

    • Evolutionary Biology
    • Bioinformatics
    • Computational Biology

    Background:

    • Molecular phylogenetic tree construction is crucial for understanding evolutionary relationships.
    • Several statistical methods exist, each with inherent assumptions and potential biases.
    • The neutral mutation model provides a framework for evaluating these methods under specific evolutionary conditions.

    Purpose of the Study:

    • To statistically evaluate the accuracy of three molecular tree construction methods: unweighted pair-group arithmetic average clustering (UPG), Farris, and modified Farris.
    • To compare these methods based on their performance in constructing tree topology and estimating branch lengths.
    • To assess the impact of gene number on phylogenetic accuracy.

    Main Methods:

    • Analysis of statistical properties under the neutral mutation model.

    Related Experiment Videos

  • Comparison of topological accuracy and branch length estimation.
  • Evaluation of the distribution, mean, and variance of relevant statistics.

    • Main Results:

    • The unweighted pair-group arithmetic average clustering (UPG) method showed the least variation in tree topology construction.
    • The modified Farris method demonstrated superior overall performance when considering both topology and branch length accuracy simultaneously.
    • Phylogenetic topologies derived from two genes were significantly more accurate than those based on a single gene.

    Conclusions:

    • The modified Farris method is recommended for accurate molecular tree construction, particularly with multi-gene datasets.
    • Researchers should be aware of the statistical nature of phylogenetic trees and potential sources of error, including nucleotide substitution stochasticity and method-specific errors.
    • Critical evaluation of published molecular trees is essential to avoid spurious evolutionary conclusions.