Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Humoral Immune Responses01:36

Humoral Immune Responses

83.5K
Overview
83.5K
Active versus Passive Immunity01:31

Active versus Passive Immunity

10.1K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
10.1K
Polymers02:34

Polymers

40.6K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
40.6K
Polymers02:34

Polymers

23.2K
23.2K
Complement System01:27

Complement System

9.9K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
9.9K
Complementation Tests00:49

Complementation Tests

6.1K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>In Situ</i> Remodeling of Tumor Microenvironment via Specific Cancer-Associated Fibroblasts Subtype Engineering to Boost Antitumor Immunity.

ACS nano·2025
Same author

Differential Cantilever Enhanced Fiber-Optic Photoacoustic Sensor for Diffusion Gas Detection.

Analytical chemistry·2024
Same author

Long-cycling and High-voltage Solid State Lithium Metal Batteries Enabled by Fluorinated and Crosslinked Polyether Electrolytes.

Angewandte Chemie (International ed. in English)·2024
Same author

Succulent-Inspired Implicit Structural Change for Smart "ON/OFF" Switchable and Flexible EMI Shielding Coating.

ACS applied materials & interfaces·2024
Same author

Global research on RNA vaccines for COVID-19 from 2019 to 2023: a bibliometric analysis.

Frontiers in immunology·2024
Same author

Macular Neural and Microvascular Alterations in Type 2 Diabetes Without Retinopathy: A SS-OCT Study.

American journal of ophthalmology·2024
Same journal

Rescuing Dendritic Cells from Adjuvant Toxicity: Liposomal Ginsenoside Rh2 as a Dual-Action Strategy for Enhanced Vaccine Potency.

Molecular pharmaceutics·2026
Same journal

First-in-Class CD146-Targeting Peptide Probes for Noninvasive PET Imaging of Melanoma.

Molecular pharmaceutics·2026
Same journal

Dual-Targeted Radionuclide Therapy with <sup>161</sup>Tb Instigates Anticancer Immunity in "Cold" Murine Prostate Tumor.

Molecular pharmaceutics·2026
Same journal

Development of [<sup>111</sup>In]In-CHX-A″-DTPA-αCD68 for ImmunoSPECT to Image Murine Macrophages.

Molecular pharmaceutics·2026
Same journal

Mechanistic Insight into Self-Gelation Involved in Prescription Design for Optimization of Tablet Performance.

Molecular pharmaceutics·2026
Same journal

[<sup>68</sup>Ga]Ga-DOTA-DP-UBI 29-41: A Novel <sup>68</sup>Ga-Labeled Ubiquicidin 29-41 Derivative Containing d-Proline for Bacterial Infection PET Imaging.

Molecular pharmaceutics·2026
See all related articles

Related Experiment Video

Updated: Jan 25, 2026

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1&#945; Nanoparticles
09:57

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

2.4K

Tailored Polymers with Complement Activation Ability To Improve Antitumor Immunity.

Chenxi Li1, Yue Lu1, Qing Chen1

  • 1School of Pharmacy , Shenyang Pharmaceutical University , Shenyang 110016 , China.

Molecular Pharmaceutics
|May 4, 2019
PubMed
Summary
This summary is machine-generated.

A novel pH-responsive micellar vaccine platform (COOH-NPs) activates the complement system to enhance immune responses. This platform shows significant potential for cancer immunotherapy by boosting antitumor effects and improving survival rates.

Keywords:
complement activationimmune responseslymph nodenucleophilic polymerspH-responsive

More Related Videos

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation
08:47

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation

Published on: March 5, 2018

9.4K
Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites
06:34

Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites

Published on: September 19, 2020

6.3K

Related Experiment Videos

Last Updated: Jan 25, 2026

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1&#945; Nanoparticles
09:57

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

2.4K
Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation
08:47

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation

Published on: March 5, 2018

9.4K
Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites
06:34

Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites

Published on: September 19, 2020

6.3K

Area of Science:

  • Immunology
  • Materials Science
  • Biotechnology

Background:

  • The complement system is crucial for innate immunity and can be leveraged for vaccine adjuvants.
  • Developing effective vaccine platforms is essential for enhancing immune responses and therapeutic outcomes.

Purpose of the Study:

  • To develop a pH-responsive micellar vaccine platform (COOH-NPs) utilizing carboxyl-modified diblock copolymers.
  • To investigate the complement-activating properties of COOH-NPs and their impact on immune responses and antitumor efficacy.

Main Methods:

  • Synthesis of carboxyl-modified poly(2-ethyl-2-oxazoline)-poly(d,l-lactide) (COOH-PEOz-PLA) copolymers.
  • Self-assembly into pH-responsive micelles (COOH-NPs) with surface hydroxyl groups.
  • In vivo evaluation of COOH-NPs in mice, including immune cell activation, antibody production, and tumor growth inhibition.

Main Results:

  • COOH-NPs significantly enhanced dendritic cell maturation, antigen-specific IgG production, and CD4+/CD8+ T-cell activation compared to control nanoparticles.
  • COOH-NPs promoted memory T-cell generation.
  • Immunization with COOH-NPs/OVA demonstrated remarkable tumor growth inhibition and prolonged survival in tumor-bearing mice.

Conclusions:

  • The developed COOH-NPs serve as an effective complement-activating vaccine platform.
  • This platform efficiently boosts immune responses, offering a promising strategy for cancer immunotherapy.
  • Leveraging complement activation is significant for advancing cancer treatment modalities.