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Related Experiment Video

Updated: Jan 25, 2026

How to Obtain Reliable Visual Event-related Potentials in Newborns
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Association between newborn screening analyte profiles and infant mortality.

Deshayne B Fell1, Lindsay A Wilson2, Steven Hawken2

  • 1Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|May 4, 2019
PubMed
Summary

Newborn screening analytes showed limited ability to predict infant mortality within the first six months of life. Further research is needed to explore predictive modeling for specific infant death causes.

Keywords:
Case-control studyepidemiologyinfant mortalitynewborn screeningpopulation health

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Area of Science:

  • Neonatal Health
  • Biomarker Discovery
  • Public Health

Background:

  • Newborn screening (NBS) typically identifies inborn errors of metabolism.
  • Exploring novel applications for NBS analytes is crucial for infant health.
  • Infant mortality remains a significant public health concern.

Purpose of the Study:

  • To evaluate if NBS analytes can predict infant mortality within the first six months of life.
  • To assess the predictive capability of various NBS analytes beyond their standard diagnostic use.
  • To identify infants at high risk for mortality using existing screening data.

Main Methods:

  • A province-wide registry linkage of NBS data with health administrative databases (2010-2014).
  • Nested case-control study design including infant deaths (7 days to 6 months) and matched controls (1:10 ratio).
  • Lasso regression used to analyze associations between mortality and NBS analytes (acylcarnitines, amino acids, hemoglobin ratio, endocrine markers, enzymes).

Main Results:

  • The study included 350 infant deaths and 3498 controls with complete data.
  • Multivariable models showed modest predictive ability for infant mortality (optimism-corrected c-statistic: 0.61).
  • NBS analytes were not strongly predictive of mortality in the general newborn population.

Conclusions:

  • Current NBS analytes lack strong predictive power for infant mortality in the general population.
  • Future research should focus on cause-specific mortality for improved prediction.
  • Investigating homogeneous subgroups may enhance the utility of predictive modeling for infant deaths.