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Efficacy of removal of a popular NSAID from aqueous solutions with metalloligs
Dean F Martin1, John Hurst1, Jacob Mayers1
1a Institute for Environmental Studies, Department of Chemistry , University of South Florida , Tampa , Florida , USA.
Abstract:
Acetaminophen, a popular NSAID (Non-steroidal anti-inflammatory drug), was studied for efficacy of removal from aqueous solutions. While Octolig® (a polyethylenediimine covalently attached to silica gel) is able to remove many simple anions and some acidic pharmaceuticals having a pKa value less than 4.5, it lacked efficacy with acetaminophen. Accordingly different transition- metal derivatives of Octolig® were tested by column chromatography using as substrates Octolig® derivatives of copper(II), cobalt(II), iron(III), manganese(II), nickel(II), and zinc(II).
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