Related Experiment Video

Updated: Jan 25, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

821

Predictors of cardiac arrhythmic events in non coronary artery disease patients

C Balla1, F Vitali2, A Brieda2

  • 1Cardiology Unit, Azienda Ospedaliero-Universitaria S. Anna di Ferrara, via A. Moro 8, Ferrara-Cona, FE, Italy. bllcst@unife.it.

BMC Cardiovascular Disorders
|May 4, 2019
PubMed

Insights

Sudden cardiac death (SCD) risk stratification is vital. This review explores novel plasma biomarkers, including microRNAs and genetic factors, for predicting ventricular arrhythmias and SCD in non-coronary artery disease patients.

Area of Science:

  • Cardiology
  • Biomarkers
  • Genetics

Background:

  • Arrhythmic sudden cardiac death (SCD) is a significant global health issue, causing 15-20% of all deaths.
  • Accurate risk stratification is essential for implementing preventive strategies.
  • Current biomarkers for SCD prediction have yielded conflicting results, limiting clinical application.

Purpose of the Study:

  • To review the role of plasma biomarkers in predicting ventricular arrhythmias and SCD.
  • To focus on patients without coronary artery disease.
  • To investigate the relationship between novel biomarkers (microRNAs, sex hormones, genetic factors) and SCD risk.

Main Methods:

  • Literature review of studies on plasma biomarkers for SCD risk prediction.
  • Focus on non-coronary artery disease populations.
  • Analysis of emerging biomarkers like microRNAs, sex hormones, and genetic markers.

Main Results:

  • Novel biomarkers such as microRNAs and sex hormones show promise in SCD risk prediction.
  • Genetic factors are an emerging area in SCD risk assessment.
  • Integration of these biomarkers may improve risk stratification in specific patient groups.

Conclusions:

  • Plasma biomarkers, particularly novel ones like microRNAs and genetic markers, hold potential for improving SCD risk prediction.
  • Further research is needed to validate these biomarkers for clinical use in non-coronary artery disease patients.
  • Combining genetic and non-genetic biomarkers may offer a more comprehensive approach to SCD risk assessment.

Keywords:
BiomarkersGenetic testingPreventionSudden cardiac death

More Related Videos

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA13:10

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA

Published on: April 24, 2017

19.2K
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

15.6K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
944
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
401
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
232
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
352
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
616
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
345