Effects of homogeneous and heterogeneous changes in the lung periphery on spirometry results

The most widespread chronic pulmonary disorders are associated with heterogeneous changes in the lung periphery and spirometry is the most commonly used test to monitor these diseases. So far only a few attempts have been undertaken to investigate the effects of lung inhomogeneity on spirometry results. The aim of this work was to evaluate whether the spirometric curve and indexes are sensitive to parallel peripheral inhomogeneities, and if the level of heterogeneity can be deduced from this test.

To this end, an enhanced computational model for forced expiration, taking into account a heterogeneous structure and properties of the respiratory system, was used. Two main phenomena were mimicked: small airways narrowing and the loss of tissue elastic recoil. Numerical simulations were performed with the model having 76 separate peripheral compartments. For a given degree of mean change, three heterogeneity levels were investigated and compared to the effects of homogeneous alterations.

All spirometric curves representing different patterns of inhomogeneous constriction, computed for each of the investigated cases, almost coincided with the curve originating from homogeneous changes, regardless of the heterogeneity level. Also the differences between the spirometric indexes obtained for heterogeneous and homogeneous alterations were negligible in comparison to their values.

The main finding is that the spirometry results are insensitive to the level of heterogeneity in the lung periphery and that it is practically impossible to distinguish between the homogeneous or heterogeneous nature of pathological processes occurring in this lung region.