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Published on: June 4, 2017
Periostin, type 2 biomarker, is not associated with asthma control grade in asthmatic allergic children
Amelia Licari1, Ilaria Brambilla1, Lucia Sacchi2
1Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Insights
Serum periostin is not a reliable biomarker for assessing allergic asthma control in children. Other factors like lung function and symptom scores are more closely linked to asthma control in clinical practice.
Area of Science:
- Pediatric Allergy
- Respiratory Medicine
- Clinical Immunology
Background:
- Allergic asthma involves type 2 inflammation.
- Periostin has been investigated as a potential type 2 biomarker.
Purpose of the Study:
- To evaluate the association between serum periostin levels and asthma control grade in children with allergic asthma.
- To determine if serum periostin can serve as a clinical biomarker for asthma control.
Main Methods:
- A cohort of 121 children with allergic asthma was studied.
- Serum periostin, lung function, FeNO, ACT questionnaire, and other inflammatory markers were assessed.
- Asthma control and severity were evaluated based on GINA guidelines.
Main Results:
- Serum periostin levels did not correlate with asthma control grade, blood eosinophils, or FeNO.
- Peripheral eosinophils, serum IgE, and FeNO were also not associated with asthma control.
- Factors like gender, lung function (FEV1, FEV1/FVC, FEF25-75), ACT scores, VAS, oral corticosteroid use, and asthma severity grade were associated with control.
Conclusions:
- Serum periostin has limited utility in assessing allergic asthma control in pediatric clinical practice.
- There is an ongoing need for reliable inflammation biomarkers that correlate with asthma control.
Background:
Allergic asthma is characterized by type 2 inflammation. Periostin has been proposed as type 2 biomarker.
Objective:
To test the hypothesis that serum periostin could be associated with the asthma control grade in a group of children with allergic asthma and recruited in clinical practice.
Patients And Methods:
121 consecutive children (71 males, 50 females, mean age 11.6 ± 3.2 years) with allergic asthma were visited for the first time at a third-level paediatric clinic. Serum periostin was evaluated with gender, BMI and z score BMI, lung function, FeNO, ACT questionnaire, VAS of breathing perception, peripheral eosinophils, total serum IgE, oral corticosteroid (CS) use in the past year, control asthma grade and asthma severity (according to GINA document).
Results:
Serum periostin was not associated with the asthma control grade and did not correlate with blood eosinophils and FeNO. In addition, peripheral eosinophils, serum IgE, and FeNO were not associated with the asthma control grade. On the contrary, gender, FEV1, FEV1/FVC ratio, FEF25-75, ACT, VAS of breathing perception, oral corticosteroid use, and asthma severity grade were associated with the asthma control grade.
Conclusions:
Serum periostin seems to be scarcely useful to assess the asthma control in children with allergic asthma in clinical practice. There is the need to identify reliable inflammation biomarkers able to correlate with the asthma control grade.
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