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Published on: June 5, 2020
Recent advances in the fabrication and application of nanomaterial-based enzymatic microsystems in chemical and
Tingting Hong1, Wenfang Liu1, Ming Li2
1Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China.
Abstract:
Novel enzymatic microsystems have strong prospects in chemical and biological analysis due to their low consumption of reagents, fast analysis time, easy manipulation and satisfactory portability. Nanomaterials (NMs) provide a favorable platform for integrating enzymes into microsystems with enhanced selectivity and sensitivity. Various NM-enzyme immobilization strategies applied in the fabrication of capillary-based and chip-based enzymatic microsystems are summarized in this manuscript. We focus on highlighting the advantages of employing NM-based enzymatic microsystems for enantioseparation, inhibitor screening, bioreaction and biosensing. Innovative nanocomposites and NM-functionalized monoliths used to construct multienzymatic microsystems are also illustrated. The general development trend identified in this review indicates that the application of NMs has significantly improved enzymatic microsystem performance.
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