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Updated: Jan 25, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Hyperintensity in the Dentate Nucleus on Nonenhanced T1-Weighted Magnetic Resonance Imaging Suggests Dechelation of
1Dalhousie University, Halifax, Nova Scotia, Canada.
Abstract:
With the exception of renal failure patients, gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging (MRI) have a high tolerance and acceptability in patients needing to undergo an enhanced MRI. Now that enhanced MRIs are becoming increasingly popular and nephrogenic systemic fibrosis cases are becoming a rarity, a common belief is that these GBCAs are essentially "biologically inert" materials. However, recent reports have emerged querying the link between these GBCAs and hyperintensity in the dentate nucleus on unenhanced T1-weighted MRI in some patients. This review article outlines the basic chemistry and characteristics of currently approved GBCAs, summarizes the described research findings of gadolinium deposition in the dentate nucleus, and identifies areas for future research.
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