Analysis of Dosimetric Impacts of Cone Beam Computed Tomography-Based Volumetric Modulated Arc Therapy Planning

To quantify the Hounsfield unit (HU) variations between computed tomography (CT) and cone beam CT (CBCT) and study its impact on volumetric modulated arc therapy (VMAT) plans.

HU number variations in CT and CBCT images were evaluated using the Catphan-504 phantom, and changes in seven different materials within the phantom (air, polymethylpentene, low-density polyethylene, polystyrene, acrylic, Delrin, and Teflon) were studied. The HU variations in half-fan and full-fan modes of CBCT were evaluated. The effect of variations in the shape of the body cross sections was assessed by reducing the body of the Catphan by 0.5 cm and 1.0 cm. CBCT-based VMAT plans in 27 patients (10 prostate, 10 brain, and 7 head and neck (HN)) were compared with corresponding CT-based plans. The dosimetric variations were assessed referring to different points on the dose volume histogram (D_5%, D_50%, and D_95% for PTVs and D_1%, D_max, and D_mean for organs at risk). The relative percentage of difference (ΔD (%)) between CT- and CBCT-based VMAT plans were examined on these points. To evaluate the dosimetric accuracy, dose distributions were compared using Omnipro-I'mRT software. The VMAT plans were evaluated based on 3 mm-3%, 2 mm-2%, and 1 mm-1% gamma criteria.

The HU difference in CT and CBCT was highest for air, Delrin, and Teflon, whereas the difference was less than 20 HU for the other materials. The dose volume histograms of both CT- and CBCT-based plans were in excellent agreement in both phantom and patients, except in HN cases where the difference was 7%. The average 3 mm-3% gamma pass points in brain, prostate, and HN patients were 97 ± 0.2%, 96 ± 0.06%, and 93.3 ± 1.1%, respectively. The gamma pass rates reduced to 88.8 ± 0.06%, 91 ± 0.04%, and 79 ± 6% in 2 mm-2%, and further declined to 76.6 ± 0.09%, 75.2 ± 0.5%, and 60 ± 6% using the stringent 1 mm-1% gamma criteria for brain, prostate, and HN cases, respectively.

Based on the results of this study, it is our belief that CBCT images can be used as a tool for evaluating the dosimetric variation in patient VMAT plans.