Related Experiment Video
Updated: Jan 25, 2026
07:06
Chronic Social Defeat Stress in Early Adolescent Male Mice
Published on: January 24, 2025
1.4K
Pubertal abnormalities in adolescents with chronic disease
K T Kao1, M Denker2, M Zacharin3
1Department of Endocrinology, Royal Children's Hospital, Melbourne, Australia; Developmental Endocrinology Research Group, Royal Hospital for Children, Glasgow, United Kingdom.
Summary
Pubertal disorders are common in adolescents with chronic disease, impacting growth and bone health. Early endocrine therapy and bone management are crucial for their well-being and development.
Area of Science:
- Pediatric Endocrinology
- Adolescent Medicine
- Chronic Disease Management
Background:
- Pubertal disorders frequently affect adolescents with chronic diseases, including inflammatory conditions or those on long-term glucocorticoid therapy.
- Adolescents with disabilities also commonly experience pubertal issues and impaired skeletal development, sometimes leading to fragility fractures.
- Chronic inflammation, glucocorticoids, and poor nutrition negatively impact the hypothalamic-pituitary gonadal axis and bone health.
Purpose of the Study:
- To highlight the prevalence and impact of pubertal disorders in chronically ill adolescents.
- To emphasize the link between pubertal dysfunction, impaired skeletal development, and fragility fractures.
- To stress the importance of addressing pubertal and bone health issues in this population.
Main Methods:
- Review of clinical presentations and endocrine management strategies for pubertal disorders in chronically ill adolescents.
- Analysis of the effects of chronic inflammation, glucocorticoids, and nutrition on pubertal development and skeletal health.
- Discussion of the role of pediatric endocrinologists in managing these complex cases.
Main Results:
- Pubertal disorders are a significant concern in adolescents with chronic diseases, affecting hypothalamic-pituitary gonadal axis function.
- Impaired skeletal development and fragility fractures are associated risks in these adolescents.
- Effective management requires a multidisciplinary approach involving endocrinologists, clinicians, patients, and families.
Conclusions:
- Addressing pubertal disorders is vital for normalizing development, promoting bone mass accrual, and ensuring linear growth in chronically ill adolescents.
- Integrated endocrine therapy for puberty and bone health is essential.
- Open communication among healthcare providers, adolescents, and families is key for successful treatment outcomes.
Keywords:
Duchenne muscular dystrophycerebral palsychronic diseaseinflammatory bowel diseaseosteoporosispubertyMore Related Videos
Related Concept Videos
01:22Chronic Obstructive Pulmonary Disease
2.4K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.4K
01:25Chronic Kidney Disease I: Introduction
613
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
613
02:23Abnormal Proliferation
5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
3.6K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.6K
01:29Chronic Obstructive Pulmonary Disease-V: Management
3.1K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
3.1K
01:24Chronic Kidney Disease II: Clinical Manifestations
601
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
601