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Long noncoding RNA/circular noncoding RNA-miRNA-mRNA axes in cardiovascular diseases
Ming Li1, Liwei Duan1, Yangxue Li2
1Department of Gastroenterology, The Second Hospital of Jilin University, 218 Ziqiang Road, Changchun 130041, China.
Life Sciences
|May 4, 2019
Summary
Non-coding RNAs, including long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs), play key roles in cardiovascular diseases (CVDs). Understanding their complex interactions, known as the lncRNA/circRNA-miRNA-mRNA axis, is crucial for developing new CVD therapies.
Area of Science:
- Molecular Biology
- Genetics
- Cardiology
Background:
- Cardiovascular diseases (CVDs) represent a significant global health burden, being the primary cause of mortality worldwide.
- Non-coding RNAs (ncRNAs), encompassing long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs), are increasingly recognized for their involvement in CVD pathogenesis.
- The intricate regulatory networks formed by these ncRNAs, specifically the lncRNA/circRNA-miRNA-mRNA axis, are emerging as critical players in cardiovascular health and disease.
Purpose of the Study:
- To review and synthesize current research on the lncRNA/circRNA-miRNA-mRNA axis in the context of various cardiovascular diseases.
- To elucidate the molecular mechanisms underlying the roles of these ncRNA interactions in CVD development.
- To highlight the potential of targeting these axes for novel therapeutic strategies in cardiovascular medicine.
Main Methods:
- Comprehensive literature review of recent studies focusing on ncRNA interactions in CVDs.
- Analysis of molecular mechanisms involving lncRNA, circRNA, miRNA, and mRNA crosstalk.
- Synthesis of findings related to specific CVDs such as atherosclerosis, myocardial infarction, hypertrophy, heart failure, and cardiomyopathy.
Main Results:
- The lncRNA/circRNA-miRNA-mRNA axis is implicated in the pathological processes of diverse cardiovascular conditions.
- These ncRNA networks regulate gene expression at multiple levels, influencing cellular functions relevant to CVDs.
- Specific examples of axis-mediated regulation in atherosclerosis, myocardial infarction, and heart failure are detailed.
Conclusions:
- The lncRNA/circRNA-miRNA-mRNA axis represents a complex regulatory system critical to cardiovascular disease development.
- Understanding these molecular interactions provides insights into disease pathogenesis and identifies potential therapeutic targets.
- Further research into this axis holds promise for advancing the treatment and prevention of cardiovascular diseases.
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