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Updated: Jan 25, 2026

Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging
Published on: June 9, 2023
A ratiometric fluorescence and light scattering sensing platform based on Cu-doped carbon dots for tryptophan and
Zhao Mu1, Jianhao Hua1, Shouai Feng2
1Faculty of Life Science and Technology, Kunming University of Science and Technology, Yunnan Province 650500, China.
Abstract:
A new Cu-doped carbon dots (Cu-CDs) were synthesized rapidly and simply via one-step thermolysis of Na2[Cu(EDTA)] and ascorbic acid (AA) at 250°C for 2h with a high quantum yield of 9.8%. The Cu-CDs exhibits two signals of fluorescence at 396nm and second-order scattering (SOS) at 617nm under a single excitation wavelength of 308nm, and can be obviously enhanced by tryptophan (Trp) or Fe(III) leading to the ratiometric fluorescence and SOS response with a good linear wider range of 0.5-250μM and 0.1-50μM, respectively. This sensing system exhibits good selectivity and sensitivity toward Trp and Fe(III) over other analytes with a low detection limit of 275nM and 46nM, respectively. Furthermore, the proposed sensing system displays a prospective application for quantitative assay of Trp and Fe(III) in practical sample.
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