Related Experiment Video
Updated: Jan 25, 2026
Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
Published on: August 13, 2015
Prenatal Maternal Depression and Neonatal Immune Responses
Jill Hahn1, Diane R Gold, Brent A Coull
1From the Department of Social and Behavioral Sciences (Hahn, McCormick, Kubzansky), The Harvard T.H. Chan School of Public Health; Channing Laboratory (Gold), Brigham and Women's Hospital, Boston; Department of Environmental Health (Gold), Biostatistics (Coull), and Environment Health (Coull), Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Division of Pulmonary, Critical Care, Sleep, and Allergy (Finn), Department of Medicine; Department of Microbiology and Immunology (Finn); Division of Nephrology (Perkins), Department of Medicine; Department of Surgery (Perkins); and Department of Bioengineering (Perkins), University of Illinois at Chicago; Channing Division of Network Medicine (Rich-Edwards), Department of Medicine, Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital and Harvard Medical School; Department of Epidemiology (Rich-Edwards), Harvard School of Public Health; and Division of Chronic Disease Research Across the Lifecourse (Rifas Shiman, Oken), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston Massachusetts.
Objective:
The aim of the study was to examine the association of lifetime maternal depression with regulation of immune responses in the infant, measured by cytokine levels and lymphocyte proliferation (LP) in cord blood mononuclear cells collected at delivery.
Methods:
We studied women recruited in early pregnancy into the Project Viva longitudinal cohort who had cord blood assayed after delivery (N = 463). Women reported about depressive symptoms in midpregnancy (Edinburgh Postnatal Depression Scale) and depression history by questionnaire. Immune responses were assayed by an index of LP, and concentrations of five cytokines (interleukin [IL]-6, IL-10, IL-13, tumor necrosis tumor necrosis factor factor α, and interferon γ) after incubation of cord blood mononuclear cells either in medium alone or stimulated with phytohemagglutinin (PHA), cockroach extract, or house dust mite extract. We examined associations of maternal depression with these sets of cytokine measures using multivariable linear or tobit regression analyses.
Results:
After adjustment for confounders (mother's age, race/ethnicity, education, household income, season of birth, and child sex), levels of IL-10 after stimulation with cockroach or dust mite allergen were lower in cord blood from ever versus never depressed women, and a similar trend was evident in IL-10 stimulated with PHA (percentage difference: cockroach extract = -41.4, p = .027; house dust mite extract = 1-36.0, p = .071; PHA = -24.2, p = .333). No significant differences were seen in levels of other cytokines or LP.
Conclusions:
Maternal depression is associated with offspring immune responses at birth, which may have implications for later life atopic risk or immune function.
Related Concept Videos
01:36Humoral Immune Responses
01:05Long-term Depression
01:40Cell-mediated Immune Responses
01:23Cells of the Adaptive Immune Response
01:29Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
01:28Cells of the Innate Immune Response
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...