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Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
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Determining Optic Nerve Cupping Using Optical Coherence Tomography (OCT) Versus a New Electronic Mobile Device.

Andrea G L Sarmento1, Adriano Sarmento2, Luiz L Souza2

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A new electronic mobile device (EMD) shows promise for glaucoma screening by accurately measuring the vertical cup-to-disc ratio (CDR). This low-cost tool may improve access to early detection, especially in remote areas.

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Area of Science:

  • Ophthalmology
  • Medical Devices
  • Diagnostic Technology

Background:

  • Glaucoma screening is crucial for early detection and prevention of vision loss.
  • Accurate measurement of the vertical cup-to-disc ratio (CDR) is key in glaucoma assessment.
  • Current methods may have limitations in accessibility and cost.

Purpose of the Study:

  • To evaluate a novel electronic mobile device (EMD) for measuring vertical CDR.
  • To compare the EMD's CDR measurements against spectral-domain optical coherence tomography (SD-OCT).
  • To assess the agreement between the EMD and clinical examiner evaluations.

Main Methods:

  • A single-masked study involving 110 eyes from 110 subjects (ages 18-60).
  • Vertical CDR was measured five times per eye using both EMD and SD-OCT.
  • Data were analyzed using Spearman correlation and Bland-Altman analysis, with comparisons to three ophthalmologists' evaluations.

Main Results:

  • Strong correlation found between EMD and SD-OCT (r=0.8319) and between EMD and examiners (r=0.7156).
  • Good agreement demonstrated between EMD and SD-OCT (95% LoA: -0.20 to 0.10).
  • Acceptable agreement also observed between EMD and examiners (95% LoA: -0.15 to 0.30).

Conclusions:

  • The EMD provides a reliable and low-cost method for vertical CDR measurement.
  • This device can serve as an alternative to subjective clinical assessments for glaucoma screening.
  • Increased accessibility to glaucoma screening is anticipated, particularly for underserved populations.