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Updated: Jan 25, 2026

Isolation of Double Negative αβ T Cells from the Kidney
Published on: May 16, 2014
A case report of double negative anti-GBM disease
Babikir Kheiri1, Mohammed Osman1, Farah Elounais1
1Internal Medicine Department, Hurley Medical Center/Michigan State University, Flint, MI, USA.
Abstract:
Goodpasture's disease is a life-threatening autoimmune disease that can lead to end stage renal disease and death. We report a case of 61-year-old female who presented with deteriorating renal function. Initial laboratory investigations were negative for autoimmune antibodies including negative anti-neutrophilic cytoplasm antibodies and anti-glomerular basement membrane (anti-GBM) antibodies using both enzyme-linked immunosorbent assay and indirect immunofluorescence. However, renal biopsy was positive for linear IgG staining. Despite starting plasmapheresis and corticosteroids treatment, her renal functions continued to deteriorate and she was started on regular hemodialysis. This case highlights the challenging presentation and diagnosis of anti-GBM disease, which requires a high clinical suspicion necessarily for early diagnosis and treatment to improve survival rates.
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