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Updated: Jan 25, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
A Case of a Cavitary Iris Melanoma with Aqueous Cytological Modulation
Lindsay A McGrath1, James F Bacon2, Paul Rundle1
1Sheffield Ocular Oncology Service, Royal Hallamshire Hospital, Sheffield, United Kingdom.
Abstract:
Malignant melanoma is the most common primary malignant tumour of the iris, but represents a small proportion of all uveal melanomas. The authors describe a 34-year-old male with a pigmented lesion of the iris. The lesion remained stable for 7 years, but the patient re-presented after this time with sudden enlargement of the mass and hyphaema. Excisional biopsy confirmed cavitary melanoma of the iris. This is the first reported case of cavitation in a primary iris melanoma. The patient has not had any further adjuvant treatment and remains metastasis free at 5 years of follow-up.
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