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Neuroinflammation is a putative target for the prevention and treatment of perioperative neurocognitive disorders
S Saxena1,2, I K Lai2, R Li2,3
1Department of Anesthesia, CHU-Charleroi, Université Libre de Bruxelles, Charleroi, Belgium.
Introduction:
The demographics of aging of the surgical population has increased the risk for perioperative neurocognitive disorders in which trauma-induced neuroinflammation plays a pivotal role.
Sources Of Data:
After determining the scope of the review, the authors used PubMed with select phrases encompassing the words in the scope. Both preclinical and clinical reports were considered.
Areas Of Agreement:
Neuroinflammation is a sine qua non for development of perioperative neurocognitive disorders.
Areas Of Controversy:
What is the best method for ameliorating trauma-induced neuroinflammation while preserving inflammation-based wound healing.
Growing Points:
This review considers how to prepare for and manage the vulnerable elderly surgical patient through the entire spectrum, from preoperative assessment to postoperative period.
Areas Timely For Developing Research:
What are the most effective and safest interventions for preventing and/or reversing Perioperative Neurocognitive Disorders.
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